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    亚博买球陈宜涛教授团队揭示白背三七通过调控PI3K/AKT和脂肪酸代谢通路降血糖作用机制
    发布单位: 生命科学学院细胞与免疫研究所(教研室)   上传时间: [2020-12-07]   浏览次数:
    近日,亚博买球生命科学学院微生物与免疫实验室陈宜涛教授研究团队在Nature旗下医学领域著名杂志《Nutrition & Diabetes》发表了题为“Gynura divaricata exerts hypoglycemic effects by regulating the PI3K/AKT signaling pathway and fatty acid metabolism signaling pathway”的研究论文。该文以传统中药白背三七为研究对象,结合网络药理学分析,验证了白背三七调控PI3K/AKT信号通路和脂肪酸代谢信号通路关键节点基因在体内发挥降血糖的最新作用机制研究。

    D9AD

    15B33

    亚博买球tangniaobing(diabetes mellitus,dm),zhongyiweizhi“xiaokezheng”、“xiaozhang”、“xiaozhong”,shiyizhongyitangdaixiewenluanweizhuyaotezhengdeneifenmidaixiezonghejibing,zhangqidegaoxuetangshuiping,kenenghuidaozhiyixiemanxingbingfazheng,birushilisangshi、shenshuaijie、shenjingsunshangyijixinxueguanjibingdeng。tangniaobingdebingyinhefabingjizhifeichangfuza,zhijinshangweiwanquanmingle,xiandaiyixuequefazhenduigaijibingdetebieyouxiaodezhiliaoshouduan。yufanghekongzhitangniaobingjiqibingfazhengyijingchengweixianjinshengwuyixuelingyuyidazhongyaoketi。zhongyaotongguoduotujing、duobadianjiangdixuetang,jianqingtangniaobingduijitidesunhai,kongzhibingyanhuantangniaobingbingfazheng。zailiaoxiaowending、duxingxiao、buliangfanyingxiaohefuyongfangbiandengfangmian,zhongyaoyouzhebuketidaideduteyoushiheguangmingdeyingyongqianjing。

    亚博买球baibeisanqi(gynura divaricata l. (gd)),youmingbaizicai,weijukesanqishuduonianshengcaoben,duoyongyuzhiliaotangniaobing、gaoxueya、gaoxuezhishenzhishuzhongaizheng,weidianxingdeyaoshiliangyongzhiwu。ju《zhongyaodacidian》jizai,beichengwei“shenxiancao”debaibeisanqiduitangniaobing、gaoxueya、gaoxuezhidengbingzhengyoujiaohaodegaishanzuoyong。daliangyaoliyanjiubaodao,gdkexianzhujiangdixuetangshuiping,gaishanzhizhidaixiebingcujinyidaoβxibaoxiufu。danshi,gddequeqiekangtangniaobingjizhirengxuchanming。

    63B54

    chenyitaojiaoshouzaizhidaoxueshengshiyan

    亚博买球zaibenyanjiuzhong,chenyitaojiaoshoutuanduifaxiangynura divaricataxianshichujiangdialt、ast、bunhecreahuoxingjiniaotang、niaojiganshuiping。jiehewangluoyaolixuefenxijishiyanyanzhengjieguo,faxiangdshuitiwukexianzhuzengjialetangniaobingdashuganzangzhongpkm1/2,p-akt,pi3k p85heglut4dedanbaibiaodashuiping,tongshizhifangsuandaixiexinhaotongluzhongdezhuduoguanjiandanbai(ampk,p-ampk,pparαhecpt1α)biaodashuipingyexianzhushangsheng。zheixiefaxianjieshilegdketongguodiaokongpi3k/akthezhifangsuandaixiexinhaotongluxianzhujiangditangniaobingdashuxuetang,bingweijinyibuchanmingchuantongzhongyaobaibeisanqikangtangniaobingdezuoyongjizhidiandinglejichu。shuoshiyanjiushengxuwenjunweigailunwendiyizuozhe,chenyitaojiaoshouweitongxunzuozhe。

    作者简介

    15D82

    亚博买球chenyitao: nan,jiaoshou,shuoshishengdaoshi,zhangqicongshiweishengwuyumianyixuejiaoxueheyanjiugongzuo。danrenshengmingkexuexueyuanxibaoyumianyiyanjiusuo(jiaoyanshi)fuzhuren、shengwukexuezhuanyezhixingfuzeren,zhejiangshengzhuanhuayixuehuilishi、zhejiangshengweishengwuxuehuilishi、shizhonglianwangluoyaolixuefenhuilishi。zhuchicanyuguojiazirankexuejijin、shengzirankexuejijin、shengjiaogaixiangmudengshengbujijiyishangxiangmu10yuxiang。jiaoxueyejikaohelianxuduonianhuoa、huoxuexiaogongzuoxianjingeren、shideshifengxianjingeren、youxiushoukejiaoshi、lidapengzhongyiyaojiaoshijiangdengrongyu。zhidaoyanjiushenghuoxiao“yanjiushengbajianchuangxinrencai”he“shijiaxueshuzhixing”,zhidaobenkeshenghuoquanguodiwujie “hulianwang+”chuangxinchuangyedasaitongjiang1xiang、shengjialeixuekejingsaihuojiang16xiang(qizhongyidengjiang4xiang)。qijinweizhifabiaoxueshulunwen50yupian,qizhongscilunwen20pian。huopizhuanli6jian、ruanjianzhuzuoquan1jian,zhubian、canbianjiaocai9bu。

    14F17

    xuwenjun: nv,weishengwuyushenghuayaoxueshuoshiyanjiusheng。zhuyaocongshizhongyaokangzhongliu、kangtangniaobingdengfangmiandeyanjiu。xianhouyidiyizuozhezainutrition & diabetes, translational cancer research,international journal of clinical and experimental medicinedengguojizhumingqikanfabiaoscilunwen3pian。

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